Overview
NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a pyridine nucleotide coenzyme present in every living cell. Structurally, NAD+ consists of two nucleotides — one containing adenine, the other nicotinamide — joined by a pair of phosphate groups. It exists in two redox states (NAD+ and NADH) and is central to cellular electron-transfer chemistry. NAD+ is supplied for in-vitro laboratory research and is not approved for human or animal use.
Research Context
NAD+ is studied across an extensive preclinical research literature spanning cellular metabolism, mitochondrial bioenergetics, sirtuin enzymology, and DNA-repair pathway research. Standard research models include cultured cell lines (often with mitochondrial reporter constructs), isolated mitochondrial preparations, and yeast and worm model organisms for cellular vitality studies. Cellular NAD+ concentrations decline measurably with age in published animal studies, driving a substantial body of research literature investigating NAD+ and its precursor compounds.
Mechanism Summary (Research Framing)
NAD+ serves as the obligate electron acceptor for a large class of enzymes (oxidoreductases) and as the substrate for several NAD+-consuming enzyme families: the sirtuin family (SIRT1 through SIRT7), studied in cellular metabolism, chromatin biology, and mitochondrial function research; PARP family poly-ADP-ribose polymerases involved in DNA damage response; CD38, an NAD+ glycohydrolase that has emerged as a major NAD+ consumer in research literature on age-related cellular metabolism; and SARM1, studied in axon-degeneration research.
Storage Parameters
Lyophilized NAD+ is stable for 24 months or longer at −20°C in its sealed vial, protected from light, moisture, and oxidative atmosphere. The compound is particularly sensitive to humidity — research labs routinely store NAD+ vials with desiccant. Reconstituted aqueous solutions (typically in Tris-HCl at pH 7.0–7.4) are significantly less stable than the lyophilized form and should be kept refrigerated and used promptly. Detailed COA and lot-specific stability information accompanies each Solira vial. See how Solira verifies every lot →
Related Research Compounds
- MOTS-c — mitochondrial-derived peptide, often studied alongside NAD+
- SS-31 (Elamipretide) — mitochondria-targeted peptide, complementary in mitochondrial research
- Epithalon — synthetic tetrapeptide studied in cellular vitality and telomere research
